(1)、Sun L, Brown R, Chen S, Zhuge Q, Su DM. 2012. Aging induced decline in T-lymphopoiesis is primarily dependent on status of progenitor niches in the bone marrow and thymus. Aging (Albany NY). 4(9):606-19.
(2)、Sun L, Guo J, Brown R, Amagai T, Zhao Y, Su DM. 2010. Declining expression of a single epithelial cell –autonomous gene accelerates age-related thymic involution. Aging Cell. 9:347-357
主要研究领域及业绩成果:在国内外工作学习期间,一直从事免疫学相关领域的实验研究。在肿瘤免疫治疗,调节性T细胞和Th17细胞分化,自身免疫以及移植免疫领域积累了大量前期工作基础。曾参与多个NIH,DOD和AACR项目。至今在国际学术刊物上已发表SCI 学术论文 20 余 篇,其中包括 Blood, Journal of Immunology, Transplantation, Transplant Immunology, Cancer Research,Journal of Molecular Medicine等刊物,论文累计影响因子为 40余点,有关调节性T细胞的综述被引用 近100次。2013年受国家基础研究重点项目(973)资助,并获2014年度获国家自然科学基金面项目资助。
代表性论文:
(1)、 Huanfa Yi, Xiaofei Yu, Chunqing Guo, Daming Zuo, and Xiang-Yang Wang, Myeloid-derived suppressor cells promote T helper 17 cell differentiation and experimental autoimmune encephalomyelitis, J Immunol, 2012 Nov 1;189(9):4295-304 (IF 5.745)
(2)、Huanfa Yi, Chunqing Guo, Xiaofei Yu, Ping Gao, Jie Qian, Daming Zuo, Masoud H. Manjili, Paul B. Fisher, John R. Subjeck, Xiang-Yang Wang, Targeting the immunoregulator SRA/CD204 potentiates specific dendritic cell vaccine-induced T cell response and antitumor immunity, Cancer Res, 2011, 71(21):6611-20. (IF 8.234).
(3)、Huanfa Yi, Daming Zuo, Xiaofei Yu, Fanlei Hu, Masoud H. Manjili, Zhengliang Chen, John R. Subjeck and Xiang-yang Wang, Suppression of antigen-specific CD4+ T cell activation by SRA/CD204 through reducing the immunostimulatory capability of antigen-presenting cell, J Mol. Med. (Berl.), 2012 , 90(4):413-26. (IF5.192)
(4)、Huanfa Yi, Xiaofei Yu, Ping Gao, Yanping Wang, Sun-Hee Baek, Xing Chen, Hyung L. Kim, John R. Subjeck, and Xiang-Yang Wang. Pattern recognition scavenger receptor SRA/CD204 down-regulates TLR4 signaling dependent CD8 T-cell activation. Blood, 2009, 113(23):5819-28.(IF 10.555)
(5)、Huanfa Yi, Yu Zhen, Chun Zeng, Lianjun Zhang, Yong Zhao. Depleting anti-CD4 monoclonal antibody (GK1.5) treatment: influence on regulatory CD4+CD25+Foxp3+ T cells in mice, Transplantation, 2008, 85(8):1167-1174.(IF 3.498)
(1)、Chen J, Zurawski G, Akagawa K, Zurawski S, Song W, Oh S, Palucka A, Banchereau J. Anti-CD40 antibody fused with Cyclin D1 as a novel vaccine for mantle cell lymphoma; 2011 Cancer Control by Tumor Suppressors and Immune Effectors (The 40th Keystone Symposia on Molecular and Cellular Discovery)
(2)、Chen J, Akagawa K, Zarawski G, Song W, Banchereau J. In vitro Cross-priming of human T cells by dendritic cells loaded with mantle cell lymphoma or Cyclin D1 antigen; 2009 Harnessing Immunity to Prevent and Treat Disease (Cold Spring Harbor)
(3)、Chen J, Zurawski G, Akagawa K, Zurawski S, Zhiqing Wang, Ueno H, Song W, Palucka K, Banchereau J. Novel vaccine for mantle cell lymphoma based on targeting cyclin D1 to dendritic cells via CD40 (submitted,2013)
(1)、Tu Z, Zhang P, Li H, Niu J, Jin X, Su L.Cross-linking of CD81 by HCV-E2 protein inhibits human intrahepatic plasmacytoid dendritic cells response to CpG-ODN.Cell Immunol. 2013 Jul-Aug;284(1-2):98-103. doi: 10.1016/j.cellimm.2013.07.012. Epub 2013 Aug 2.( 通讯作者 ) 影响因子IF: 2.67)
(2)、Tu Z, Hamalainen-Laanaya HK, kuroki Y , Crispe IN, Orloff MS. HCV Core and NS3 protein manipulate human blood-derived dendritic cell development and promote Th-17 differentiation INTERNATIONAL IMMUNOLOGY Volume: 24 Issue: 2 Pages: 97-106 Published: FEB 2012. (通讯作者) (影响因子IF: 3.543)
(3)、Tu Z, Hamalainen-Laanaya HK, Crispe IN, Orloff MS.
Synergy between TLR3 and IL-18 promotes IFN-c dependent TRAIL expression in human liver NK cells,
(4)、Tu Z, Pierce RH, Kurtis J, kuroki Y, Crispe IN, Orloff MS. Hepatitis C Virus Core Protein Subverts the Anti-Viral Activities of Human Kupffer Cells
(1)、Wang S, Tricot G, Shi L, et al. RARalpha2 expression is associated with disease progression and plays a crucial role in efficacy of ATRA treatment in myeloma. Blood. 2009 Jul 16;114(3):600-7. (影响因子: 10.558, 他引次数: 12)
(2)、Wang S, Hong S, Wezeman M, Qian J, Yang J, Yi Q. Dendritic cell vaccine but not idiotype-KLH protein vaccine primes therapeutic tumor-specific immunity against multiple myeloma. Front Biosci. 2007 May 1;12:3566-75.(影响因子: 4.048, 他引次数: 12)
(3)、Wang S, Hong S, Yang J, Qian J, Zhang X, Shpall E, Kwak LW, Yi Q. Optimizing immunotherapy in multiple myeloma: Restoring the function of patients' monocyte-derived dendritic cells by inhibiting p38 or activating MEK/ERK MAPK and neutralizing interleukin-6 in progenitor cells. Blood. 2006 Dec 15;108(13):4071-7. (影响因子: 10.558, 他引次数:70)
(4)、Wang S, Yang J, Qian J, Wezeman M, Kwak LW, Yi Q. Tumor evasion of the immune system: inhibiting p38 MAPK signaling restores the function of dendritic cells in multiple myeloma. Blood. 2006 Mar 15;107(6):2432-9. (影响因子: 10.558, 他引次数:66)
(1)、Wang X, Zaharia A, Trask H, Gorman N, Szakacs J, Dwyer B, Yohe H, Balestran, D, Sinclair J and Sinclair P. Differential Uptake and Metabolic Effects of Iron Chelates in Hepatocytes and Kupffer Cells in Chick Embryo Liver Cultures. Blood. Submitted
(2)、 Wang X, Kumanogoh A, Watanabe C, Shi W, Yoshida K and Kikutani H. Functional soluble CD100/Sema4D released from activated lymphocytes: possible role in normal and pathological immune responses. Blood Vol. 97(11): 3498-504, Jun.1 2001 被引用次数:80
(3)、Wang X, Kumanogoh A, Watanabe C, Shi W, Yasui T, Yoshida K and Kikutani H. Correlation of soluble CD100 levels with development of autoimmune disease. Leucocyte Typing VII. P662-663, 2000. Oxford University Press, ISBN 0-19-263252-3.
(1)、 Yong Cai, Kitajima S., Etoh F., Kinoshita, S., Okubo, K., Hamasaki, N (1997) Autoantibody reactive with the human general transcription factor TFIIF in sera from patient with autoimmune disorders. Clinical and Experimental Immunology, 109, 488-94.
(2)、 Yong Cai, Mitsuyasu, M., Zhang, C., Hamasaki, N., Kitajima, S (1998) Structure of human transcription factor TFIIF revealed by limited proteolysis with trypsin. FEBS Letters, 43, 191-4.
(3)、Yong Cai, Zhang, C., Nawa, T., Aso, T., Tanaka, M., Oshiro, S., Ichijo, H., Kitajima, S (2000) Homocysteine-responsive ATF3 gene expression in human vascular endothelial cells: activation of c-Jun NH2-terminal kinase and promoter response element. Blood, 96, 2140-8.
(4)、Yong Cai, Jin, J., Tomomori-Sato, C., Sato, S., Sorokin, I., Parmely, TJ., Conaway, RC. and Conaway, JW (2003) Identification of new subunits of the multiprotein mammalian TRRAP/TIP60-containing histone acetyltransferase complex. Journal of Biological Chemistry, 278, 42733-6. (co-first author)
(5)、Yong Cai, Jin, J., Florens, L., Swanson, SK., Kusch, T., Li, B., Workman, JL., Washburn, MP., Conaway, RC., and Conaway, JW (2005) The mammalian YL1 protein is a shared subunit of the TRRAP/TIP60 histone acetyltransferase and SRCAP complexes. Journal of Biological Chemistry, 280, 13665-70. (co-first author)
(6)、Yong Cai, Jingji Jin, Aaron J. Gottschalk, Tingting Yao, Joan W. Conaway and Ronald C. Conaway (2006) Purification and assay of the human INO80 and SRCAP chromatin remodeling complexes. Methods, 40, 312-17.
(7)、Yong Cai, Jin, J., Swanson SK, Cole MD, Choi SH, Florens LF, Warshburn MP, Conaway JW, and Conaway RC. Subunit composition and substrate specificity of a MOF-containing histone acetyltransferase distinct from the male-specific lethal (MSL) complex. Journal of Biological Chemistry, 2010, 285: 4268-72.
(十)金景姬
1、个人简历:女,52岁,教授,博士生导师。1980.7 -1985.7白求恩医科大学医学专业医学学士学位,1985.7 -1987.8延边大学基础医学部药理学研究室助教1987.9 - 1989.12延边大学基础医学部药理学专业硕士学位,1990.1-1992.10,延边大学基础医学部药理学研究室讲师,1992.10-1993.3日本九州大学药学部药效解析学研究室自费公派留学,1993.4-1996.4日本九州大学药学部大学院药学博士学位,1996.4–2001.3日本Panapharm Laboratories, Co. Ltd课题组组长研究员.2001.3-2001.6美国Oklahoma Medical Fundation博士后,2001.6–2009.9美国Stowers Institute for Medical Research高级研究员等博士后,2009.10–至今,吉林大学生命科学学院博士生导师、教授。
(1)、Jingji Jin, Yong Cai (co-first author), Tingting Yao, Aaron J. Gottschalk, Laurence Florens, Selene K. Swanson, José L. Gutiérrez, Michael K. Coleman, Jerry L. Workman, Arcady Mushegian, Michael P. Washburn, Ronald C. Conaway*, and Joan Weliky Conaway*. A Mammalian Chromatin Remodeling Complex with Similarities to the Yeast INO80 Complex. . Journal of Biological Chemistry, 2005, 280, 41207-12. (IF 4.7)
(2)、Jingji, Jin, Yong Cai, Li, B, Conaway, RC, Conaway JW, Workman, JL. and Kusch, T*. In and out: Histone variant exchange in chromatin. Trends in Biochemical Sciences, 2005, 30, 680-87. (IF 13.1)
(1)、Zhang L, Jiang C, Zhang H, Gong X, Yang L, Miao L, Shi Y, Zhang Y, Kong W, Zhang C, Shan Y*.A novel modified peptide derived from membrane-proximal external region of human immunodeficiency virus type 1 envelope significantly enhances retrovirus infection.J Pept Sci. 2014 Jan;20(1):46-54. doi: 10.1002/psc.2587. Epub 2013 Nov 19.
(2)、Zhang L, Miao L, Gong X, Zhang H, Yang L, Shi Y, Kong W, Jiang C, Shan Y*.Multiple antigen peptide mimetics containing gp41 membrane-proximal external region elicit broad neutralizing antibodies against human immunodeficiency virus type 1 in guinea pigs.J Pept Sci. 2013 Aug;19(8):491-8. doi: 10.1002/psc.2526. Epub 2013 Jun 21.
(3)、Wang X, Zhang B, Xu D, Gao J, Wang L, Wang Z, Shan Y*, Yu X*. Purification, crystallization and preliminary X-ray crystallographic analysis of the CIDE-N domain of Fsp27. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 Dec 1;68(Pt 12):1529-33. doi: 10.1107/S1744309112043989. Epub 2012 Nov 14.
(4)、Shan Y, Liu J, Rath NP, Gokel GW.Rapid acyl migration between pyrogallyl 1,2- and 1,3-dipivaloates. Nat Prod Commun. 2012 Mar;7(3):333-6.
(5)、Synthesis of magnetic and fluorescent multifunctional hollow silica nanocomposites for live cell imaging.Sun L, Zang Y, Sun M, Wang H, Zhu X, Xu S, Yang Q, Li Y, Shan Y*.J Colloid Interface Sci. 2010 Oct 1;350(1):90-8. doi: 10.1016/j.jcis.2010.06.041. Epub 2010 Jun 20.