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细胞生物学博导 孙天盟

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  孙天盟2011年于中国科学技术大学获细胞生物学专业博士学位。2012年至2014年在美国佐治亚理工学院生物医学工程系(Department of Biomedical Engineering, Geogia Institute of Technology)从事博士后研究工作。2014年3月回国,目前为吉林大学白求恩第一医院教授,吉林省“长白山学者”特聘教授。主要从事纳米药物递送系统用于肿瘤免疫治疗及抑制移植免疫排斥的研究工作,并获得2014年“国家自然科学基金优秀青年科学基金”项目资助。已发表SCI收录学术论文23篇,其中以第一作者和共第一作者身份在Science Translational Medicine,Angewandte Chemie International Edition,ACS Nano和Biomaterials等杂志发表论文8篇,总影响因子约为70,申请发明专利3项,一项获得授权。                                                                               

 

主要成果

1 Y. D. Yao#, T. M. Sun#, S. Y. Huang, S. Dou, L. Lin, C. Q. Mao, F. Y. Yu, M. S. Zeng, J. Y. Zang, F. X. Su, P. Zhang, J. Lieberman*, J. Wang*, E. W. Song*, Targeted Delivery of PLK1-siRNA by ScFv Suppresses Her2+ Breast Cancer Growth and Metastasis. Science Translational Medicine 2012, 4, 30-48                

2 T. M. Sun, Y. S. Zhang, B. Pang, D. C. Hyun, M. Yang, Y. Xia*, Engineered Nanoparticles for Drug Delivery in Cancer Therapy. Angewandte Chemie International Edition 2014, 53, 12320-64                  

3 J. Z. Du#, T. M. Sun#, W. J. Song, J. Wu, J. Wang*, A Tumor-Acidity-Activated Charge-Conversional Nanogel as an Intelligent Vehicle for Promoted Tumoral-Cell Uptake and Drug Delivery. Angewandte Chemie International Edition 2010, 49, 3621-6                                             

4 T. M. Sun, J. Z. Du, Y. D. Yao, C. Q. Mao, S. Dou, S. Y. Huang, P. Z. Zhang, K. Leong, E. W. Song*, J. Wang*, Simultaneous Delivery of siRNA and Paclitaxel via a “Two-in-One” Micelleplex Promotes Synergistic Tumor Suppression. ACS Nano, 2011, 5, 1483–94                                          

5 T. M. Sun, Y. C. Wang, F. Wang, J. Z. Du, C. Q. Mao, C. Y. Sun, R. Z. Tang, Y. Liu, J. Zhu, Y. H. Zhu, X. Z. Yang, J. Wang*, Cancer Stem Cell Therapy Using Doxorubicin Conjugated to Gold Nanoparticles via Hydrazone Bonds. Biomaterials 2014, 35, 836-45                                           

6 T. M. Sun, J. Z. Du, L. F. Yan, H. Q. Mao, J. Wang*, Self-Assembled Biodegradable Micellar Nanoparticles of Amphiphilic and Cationic Block Copolymer for siRNA Delivery. Biomaterials 2008, 29, 4348-55                                                                            

7 T. M. Sun, Y. Wang, Y. C. Wang, J. Xu, X. Zhao, S. Vangveravong, R. H. Mach, Y. Xia*, Using SV119-gold Nanocage Conjugates to Eradicate Cancer Stem Cells Through a Combination of Photothermal and Chemo Therapies. Advanced Healthcare Materials, 2014, 3, 1283-91                           

8 J. Wu#, T. M. Sun#, X. Z. Yang, J. Zhu, Y. C. Wang, F. Wang, J. Z. Du, C. Q. Mao, C. Y. Sun, R. Z. Tang, Y. Liu, J. Zhu, X. Z. Yang, J. Wang*, Enhanced Drug Delivery to Hepatocellular Carcinoma with a Galactosylated Core-Shell Polyphosphoester Nanogel. Biomaterials Science 2013, 1, 1143-50    

 

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