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免疫学博导/细胞生物学硕导 伊焕发

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  伊焕发,现为吉林大学教授,博士生导师。2012年白求恩第一医院“资深博士后”引进人才、特聘教授。1996年获得大连医科大学临床医学专业医学学士学位,2002年获得北京大学医学部人体解剖学与组织胚胎学专业硕士,2007年毕业于中国科学院动物研究所,获得细胞生物学博士学位。在美国Roswell park cancer Institute、Virginia Commonwealth University/Massey Cancer Center进行博士后研究,主要研究方向为免疫耐受及免疫调节在移植免疫、肿瘤免疫和自身免疫疾病的基础及应用研究。曾参与多个NIH、DOD和AACR项目。至今在国际学术刊物上已发表 SCI 学术论文 20 余 篇,其中包括Cell stem cell, Blood、J Immunol、Cancer Res、Transplantation、Transpl. Immunol、J Mol. Med.、Hepatology等刊物,第一作者11篇,至今SCI论文总影响因子为100余点,被引用超过 400次。参编外文图书1部。中文文章10余篇,其中第一作者7篇。目前作为项目负责人主持国家及省部级课题4项,校级课题1项;作为课题骨干参与“十二五病毒性肝炎重大专项”1项。

 

联系方式:

88783042    

yihuanfa@jlu.edu.cn

 

 

教育背景

2004.9- 2007.7  中国科学院动物研究所  细胞生物学    博士

1999.8-2002.7  北京大学医学部  解剖学与组织胚胎学   医学硕士

1991.8-1996.7  大连医科大学    临床医学系           医学学士

 

工作及研究经历

2012.2-至今   吉林大学白求恩第一医院转化医学研究院  教授/博士生导师

2009.7-2012.1  美国弗吉尼亚联邦大学医学院           博士后

2007.8-2009.6  美国罗斯威尔帕克癌症研究中心         博士后

2002.7-2004.7  大连医科大学 基础医学院              讲师

1996.7-1999.7  大连医科大学 基础医学院              助教

 

科研课题

1. 伊焕发:干细胞分化产生的免疫原性与免疫耐受诱导子课题3通过基因工程技术修饰多能干细胞及改善免疫微环境,建立安全有效的免疫耐受策略(2013CB966903),国家重点基础研究发展计划,2013-2015,278万

2.伊焕发:髓性抑制细胞促进Th17细胞分化的机制及其在移植免疫中的应用,国家自然科学基金面上项目,2014.01-2017.12,70万

3. 伊焕发:髓系来源抑制性细胞调节Th17细胞分化在移植免疫中的作用及机制,吉林大学“白求恩计划B”项目,2012.01-2013.12,10万

4.伊焕发: 髓系来源抑制性细胞调节Th17细胞分化在移植免疫中的作用及机制(20140413058G),吉林省科技厅国际合作项目, 2014.01-2016.12, 8万

5. Scavenge receptor and immune regulation美国国立癌症研究所课题(CA12911) 主要完成人

6. 以大分子量热休克蛋白为佐剂的肿瘤疫苗研究 美国国立癌症研究所课题(CA12848)第二完成人

7. Improving Cancer Radiotherapy by an SR-A-Silenced Dendritic Cell Vaccine美国癌症协会课题 RSG-08-187-01-LIB 第二完成人

8. 硒对结肠肿瘤的作用研究 大连医科大学 基础医学院大学生科研项目 主持人

9. 人树突状细胞与肺癌细胞融合的研究 国家自然科学基金项目(39970380)主要完成人

 

主要发表和待发表文章:

1.   Yi H, Guo C, Yu X, Zuo D, Wang XY. Mouse CD11b+Gr-1+ myeloid cells can promote Th17 cell differentiation and experimental autoimmune encephalomyelitis. J Immunol. 2012 Nov 1;189(9):4295-304.IF: 5.788

2.   Guo C, Yi H, Yu X, Zuo D, Qian J, Yang G, Foster BA, Subjeck JR, Sun X, Mikkelsen RB, Fisher PB,Wang XY. In situ vaccination with CD204 gene-silenced dendritic cell, not unmodified dendritic cell, enhances radiation therapy of prostate cancer. Mol Cancer Ther. 2012 Nov;11(11):2331-41. IF:5.226

3.   Zuo D, Yu X, Guo C, Wang H, Qian J, Yi H, Lu X, Lv ZP, Subjeck JR, Zhou H, Sanyal AJ, Chen Z, Wang XY. Scavenger receptor SRA restrains T cell activation and protects against concanavalin A-induced hepatic injury. Hepatology. 2012 Jul 23. doi: 10.1002/hep.25983. [Epub ahead of print]  IF:11.665

4.   Zuo D, Yu X, Guo C, Yi H, Chen X, Conrad DH, Guo TL, Chen Z, Fisher PB, Subjeck JR, Wang XY.Molecular chaperoning by glucose-regulated protein 170 in the extracellular milieu promotes macrophage-mediated pathogen sensing and innate immunity.FASEB J. 2012 Apr;26(4):1493-505. IF:5.712

5.   Yi H, Zuo D, Yu X, Hu F, Manjili MH, Chen Z, Subjeck JR, Wang XY. Suppression of antigen-specific CD4+ T cell activation by SRA/CD204 through reducing the immunostimulatory capability of antigen-presenting cell.J Mol Med (Berl). 2012 Apr;90(4):413-26. IF:4.668

6.   Guo C, Yi H, Yu X, Hu F, Zuo D, Subjeck JR, Wang XY. Absence of scavenger receptor A promotes dendritic cell-mediated cross-presentation of cell-associated antigen and antitumor immune response.Immunol Cell Biol. 2012 90(1):101-8. IF:3.661

7.   Zuo Daming, Yu Xiaofei, Guo Chunqing, Yi Huanfa, Chen Xing, Conrad DH, Guo TL, Chen Z, Fisher PB, Subjeck JR, Wang XY. Molecular chaperoning by glucose-regulated protein 170 in the extracellular milieu promotes macrophage-mediated pathogen sensing and innate immunity. FASEB J. 2011 Dec 29. doi:10.1096/fj.11-197707fj.11-197707.

8.   Huanfa Yi, Chunqing Guo, Xiaofei Yu, Ping Gao, Jie Qian, Daming Zuo, Masoud H. Manjili, Paul B. Fisher, John R. Subjeck, Xiang-Yang Wang, Targeting the immunoregulator SRA/CD204 potentiates specific dendritic cell vaccine-induced T cell response and antitumor immunity, Cancer Res, 2011, 71(21):6611-20. (IF 8.234).

9.   Huanfa Yi, Daming Zuo, Xiaofei Yu, Fanlei Hu, Masoud H. Manjili, Zhengliang Chen, John R. Subjeck and Xiang-yang Wang, Suppression of antigen-specific CD4+ T cell activation by SRA/CD204 through reducing the immunostimulatory capability of antigen-presenting cell, J Mol. Med. (Berl.), 2012 , 90(4):413-2. DOI: 10.1007/s00109-011-0828-1 (IF5.192) 

10.  Jie Qian, Huanfa Yi, Chunqing Guo, Xing Chen, John R. Subjeck, and Xiang-Yang Wang, CD204 suppresses large heat shock protein-facilitated priming of tumor antigen gp100-specific T cells and chaperone vaccine activity against mouse melanoma, J Immunol, 2011, 187(6):2905-14.  (co-first author, IF 5.745)

11.  Xiaofei Yu, Huanfa Yi, Chunqing Guo, Daming Zuo, Yanping Wang, Hyung Kim, John R. Subjeck, and Xiang-Yang Wang, Pattern recognition scavenger receptor-A attenuates toll-like receptor 4 induced NF-kappa B activation by directly inhibiting ubiquitination of TNF receptor associated factor 6, J Biol Chem, 2011 , 286(21):18795-806. (IF5.328,引用4次)

12.  Chunqing Guo, Huanfa Yi, Xiaofei Yu, Fanlei Hu, Daming Zuo, John R. Subjeck and Xiang-Yang Wang, Absence of scavenger receptor A promotes dendritic cell-mediated cross-presentation of cell-associated antigen and antitumor immune response, Immunol Cell Biol,  2012 90(1):101-8. doi:10.1038/icb.2011.10. (IF 3.741)

13.  Fanlei Hu, Xiaofei Yu, Hongxia Wang, Damong Zuo, Chunqing Guo, Boaz Tirosh, Huanfa Yi , Xiaoyan Qiu, and Xiang-Yang Wang, ER stress and its regulator X-box binding protein-1 enhances TLR3 induced inflammatory response in dendritic cells, Eur J Immunol, 2011, 41(4):1086-97. (IF 4.942,引用3次)

14.  Huanfa Yi, Masoud H. Manjili, Elizabeth A. Repasky, Xiang-Yang Wang, Adoptive cell therapy of prostate cancer using female mice-derived T cells reactive with tumor-associated prostate antigens, Cancer Immunol Immunother 2011, 60(3):349-60.(IF 4.29)

15.  Huanfa Yi, Xiaofei Yu, Ping Gao, Yanping Wang, Sun-Hee Baek, Xing Chen, Hyung L. Kim, John R. Subjeck, and Xiang-Yang Wang. Pattern recognition scavenger receptor SRA/CD204 down-regulates TLR4 signaling dependent CD8 T-cell activation.  Blood, 2009, 113(23):5819-28.(IF 10.555,引用14次)

16.  Huanfa Yi, Yu Zhen, Chun Zeng, Lianjun Zhang, Yong Zhao. Depleting anti-CD4 monoclonal antibody (GK1.5) treatment: influence on regulatory CD4+CD25+Foxp3+ T cells in mice, Transplantation, 2008, 85(8):1167-1174.(IF3.498,引用12次)

17.  Huanfa Yi, Jialin Zhang, Yong Zhao. The effects of antibody treatment on regulatory CD4+CD25+ T cells. Transpl Immunol, 2008, 19(1):37-44.(IF2.439,引用6次)

18.  Huanfa Yi, Yong Zhao. Chemokine, Chemokine receptor and naturally occurring CD4+CD25+ regulatory T cells, Expert Rev Clin Immunol, 2007, 3(3):343-349.

19.  Huanfa Yi, Liangjun Zhang, Yu Zhen, Yong Zhao. Dendritic cells generated from GM-CSF and IL-5 with a tolerance phenotype, Cytokine, 2007, 37(1):35-43.(IF3.123,引用6次)

20.  Chun Zeng, Yu Zhen, Shang-an Shu, Tinghe Wu, Huanfa Yi, Zhe-Xiong Lian, and Yong Zhao. The influence of cyclosporin A on B and T lymphocyte attenuator expression, J Autoimmunity, 2007, 28(4):234-44 (IF7.231,引用11次)

21. Tinghe Wu, Yu Zhen, Chun Zeng, Huanfa Yi, Yong Zhao. B and T lymphocyte attenuator interacts with CD3 zeta and inhibits phosphorylated form of TCR zeta accumulation in the lipid raft during T cell activation. Immunol Cell Biol, 2007, 85(8):590-5.(IF4.2,引用10次)

22.  Huanfa Yi, Yu Zhen, Lingling Jiang, Jialin Zheng, Yong Zhao. The phenotypic characterization of naturally occurring regulatory CD4+CD25+ T cells, Cellular& Molucular Immunology, 2006, 3(3):189-195.(IF2.765,引用105次),

23. Zuyue Sun, Liang Zhao, Hongjun Wang, Liguang Sun, Huanfa Yi, Yong Zhao. Presence of Functional Mouse Regulatory CD4+CD25+T Cells in Xenogeneic Neonatal Porcine Thymus-Grafted Athymic Mice. Am J Transplantation, 2006, 6(12): 2841–2850. (IF6.433,引用20次)

24.  Lianjun Zhang, Huanfa Yi, Xuepei Xia,Yong Zhao. Transforming growth factor-beta: an important role in CD4+CD25+ regulatory T cells and immune tolerance. Autoimmunity, 2006, 39(4):269-76(IF2.813,引用47次)

 

其他文章:

1.     伊焕发,唐军民,唐岩等。人外周血树突状细胞与肺鳞癌细胞的融合研究,解剖学报,2003,34(5):496-499。

2.     伊焕发,唐军民,唐岩等。人外周血树突状细胞与乳腺癌细胞融合,解剖学杂志,2003,26(2):105-108

3.     伊焕发,唐岩,甄昱等。人外周血CD4+树突状细胞的纯化及鉴定,解剖科学进展,2003,9(3):193-196

4.     唐岩,唐军民,李银生,伊焕发等。免疫磁珠技术在分离人外周血树突状细胞中的应用,解剖学杂志,2003,26(3):298-300

5.     伊焕发,唐军民。树突状细胞与肿瘤细胞之融合细胞在抗肿瘤免疫中的研究进展,解剖学报,2003,34(6):665-666

6.     伊焕发,伊焕忻,陈要武。树突状细胞的临床研究进展,国外医学肿瘤分册,2003,30(6):421-424

7.     马晓凯,伊焕发,唐军民。树突状细胞研究进展,大连医科大学学报,2002,24(4):307-310

8.     伊焕发,唐军民, 唐岩, 孙红亚, 甄昱,人肺麟癌细胞系LTEP78与外周血树突状细胞融合的观察,解剖学杂志,2002, 25(suppl):227-228.

9.     汪涛,唐军民,舒丹毅,唐岩,伊焕发,小鼠成肌细胞的体外培养及生物学特性观察,天津医科大学学报,2002, 8(2):182-186

10.  唐岩,唐军民, 李银生, 伊焕发,免疫磁珠技术分离树突状细胞,四川解剖学杂志,2002, 9(2):110.(会议摘要)

11.  李银生,雷素英,田素民,伊焕发,褪黑激素对吗啡依赖小鼠肝损害治疗作用的病理学研究,新乡医学院学报,2001, 17(5):318-320.

12.  隋鸿锦,宫瑾,于胜波,伊焕发等,海人酸诱导癫痫大鼠齿状回神经肽Y能苔状纤维侧枝发芽,解剖学杂志,2000, 23(5):424-427

13.  隋鸿锦,宫瑾,于胜波,伊焕发等,海人酸诱导癫痫大鼠齿状回分子层突触可塑性变化的定量研究,2000,解剖学报,2000, 31(suppl):121-123.

14.  徐飞,赵薇,伊焕发,大连市汉族学生二十年形态指标生长发育的比较研究,Am. J Comp. Med.,1999, 1(11):746-750.

 

参编图书

Xiang-Yang Wang, Huanfa Yi, Xiaofei Yu, Damin Zuo, and John R. Subjeck, (in press) Enhancing antigen cross-presentation and T-cell priming by complexing protein antigen to recombinant large heat-shock protein. Methods Mol Biol.2011, 787:277-87.  2011, Springer Science+Business Media, LLC

 

会议摘要

1. Huanfa Yi,*, Jie Qian,*, Chunqing Guo, Xiaofei Yu, Daming Zuo, John R. Subjeck, and Xiang-Yang Wang, INNATE PATTERN RECOGNITION RECEPTOR SRA/CD204 RESTRICTS DENDRITIC CELL FUNCTIONS AND ANTITUMOR IMMUNITY, VCU Massey 2011 Research Retreat, November, 2011 (poster).

2. Daming Zuo, Huanfa Yi, Xiaofei Yu and Xiang-Yang Wang, Large stress protein interactions with pathogen-associated molecules and its implications in host immunity and vaccine design, VCU Massey 2010 Research Retreat, October, 2010 (poster,二等奖).

3. Chunqing Guo, Huanfa Yi, Xiaofei Yu, and Xiang-Yang Wang, Dendritic cells vaccination targeting scavenger receptor A enhances antitumor efficacy of conventional radiotherapy, VCU Massey 2010 Research Retreat (poster), October, 2010

4. Huanfa Yi, Xiaofei Yu, Ping Gao, John R. Subjeck and Xiang-Yang Wang, Scavenger receptor-A(SR-A) down-regulates Toll-like receptor 4(TLR4) agonist induced adaptive immune response, 6th International Cancer Vaccine Symposium, New York, NY, October, 2008(Poster)