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免疫学博导/细胞生物学硕导 杨永广

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杨永广,教授,医学博士,博士生导师。国家中组部“千人计划”特聘专家,国家杰出青年科学基金获得者(B类),国家重大科学研究计划(973计划)首席科学家,国家“十二五”科技重大传染性疾病专项项目首席科学家,教育部2011年度“长江学者与创新团队发展计划”负责人,吉林大学白求恩第一医院转化医学研究院副院长,吉林大学免疫学研究所所长,表观遗传药物与人类疾病动物模型国际联合研究中心主任,人类疾病动物模型国家地方联合工程实验室主任,吉林省组织工程与人类疾病动物模型重点实验室主任。

在美国哈佛大学和哥伦比亚大学医学院工作20余年,先后任讲师、助理教授、副教授、终身教授。专长于移植免疫学,主要包括同种异基因和异种器官移植免疫耐受及骨髓移植。在移植免疫耐受、骨髓移植、干细胞移植和免疫系统人源化小鼠构建及应用的研究领域中取得了显著成绩。

首次证明造血嵌合体能够诱导预先存在和新发育的产生a1, 3Gal 抗体前B细胞的免疫耐受;建立的具有人免疫系统/血液系统的人源化小鼠模型被认为是可用于评价人免疫系统的最好模型之一, 已经成功地应用该模型对人异基因和异种免疫反应与免疫耐受及其他人免疫生物学和免疫病理学进行研究; 被认为是CD47移植排斥作用研究领域的先驱,首次发现并证明了巨噬细胞免疫耐受现象及CD47不相容性是触发巨噬细胞异种移植排斥的主要机制。截止2015年4月发表SCI论文 96篇,被引用3009次,累计影响因子总和610.75点。

 

教育背景

1979.9-1984.6   北华大学医学院  临床医学专业                                              学士

1984.9-1987.6   吉林大学白求恩医学部  放射医学                                          硕士

1987.9-1991.5   吉林大学白求恩医学部  辐射免疫学                                      博士

1989.11-1991.3  日本北里大学医学部    免疫学                               联合培养博士

 

工作经历 

1991.5-1992.8     吉林大学白求恩医学部                                                        讲师

1992.8-1994.3     日本三菱化学生命科学研究所                                特别研究员

1994.4-1997.2     美国哈佛大学医学院                                                        博士后

1997.3-2000.2     美国哈佛大学麻省总医院移植生物学中心        助理免疫学家

2000.3-2006.10   美国哈佛大学麻省总医院移植生物学中心                助理教授

2002.1-2010.2     美国哈佛大学麻省总医院移植生物学中心            高级研究员

   干细胞移植免疫实验室                                                     主任

2005.8-2010.2     美国哈佛大学麻省总医院移植生物学中心            副免疫学家

2006.11-2010.2   美国哈佛大学医学院                                                        副教授

2007.1-2011.6     吉林大学                                                                        客座教授

2010.3-至今         美国哥伦比亚大学                                                               教授

2010.3-至今         美国哥伦比亚大学转化免疫学中心                       高级研究员

                                                                                                                实验室主任

2011.6-至今         吉林大学                                               国家千人计划特聘教授

2011.6-至今        吉林大学白求恩第一医院转化医学研究院                      教授

                                                                                                                      副院长

 2011.6-至今        吉林大学免疫学研究所                                                      所长

 

主要学术任职

美国移植协会 (American Society of Transplantation)                                   会员

国际移植协会 (The Transplantation Society)                                                会员

国际异种移植协会 (International Xenotransplantation Association)            会员

美国免疫学家协会 (American Association of Immunology)                        会员

美国血液学协会 (American Society of Hematology)                                    会员

中国免疫学会移植免疫学分会                                                                     组委

中国生物医学工程干细胞技术分会                                                             委员

 

国际杂志编委

国际移植学会杂志Transplantation                                                              编委

国际异种移植学会杂志Xenotransplantation                                               编委

Cellular & Molecular Immunology                                                                编委

The Open Transplantation Journal                                                                 编委

The Open Transplantation Letter                                                                   编委

The Open Transplantation Reviews                                                               编委

International Journal of Medical Sciences                                                     编委

ISRN Hematology                                                                                         编委

 

国际杂志审稿专家

Nature                                                                                                    审稿专家

Nat Med                                                                                                 审稿专家

JCI                                                                                                         审稿专家

PNAS                                                                                                    审稿专家

  Blood                                                                                                    审稿专家

JI                                                                                                           审稿专家

Cytokines                                                                                              审稿专家

Life Science                                                                                         审稿专家

Clinical & Experimental Immunology                                                审稿专家

Bone Marrow transplantation                                                              审稿专家

Haematologica                                                                                     审稿专家

 

科研项目及平台资助

1.         经乙型肝炎进展为肝癌的人源化小鼠和细胞模型的建立及个体化治疗,国家科技重大专项,2013ZX10002008,2013.01-2015.12,资助1531万

2.         造血干细胞移植的免疫学基础研究,国家重大科学研究计划(973计划),2015CB964400,2015.01-2019.12,资助2625万

3.         移植免疫,教育部长江学者与创新团队资助,IRT1133,2012.01-2014.12,资助300万

4.         自发性I型糖尿病人源化小鼠疾病模型的构建,国家自然科学基金面上项目,81273334,2013.01-2016.12,资助120万元

5.         阐明人多能干细胞分化产生的免疫原性及其与免疫系统相互作用机制,国家重点基础研究发展计划(973计划)子课题,2013CB966902,2013.01-2017.12, 资助394.7万元

6.         人类疾病动物模型国家地方联合工程实验室,吉林省发展改革委员会,资助200万元

7.         吉林省组织工程与人类疾病动物模型重点实验室,吉林省科学技术厅,资助30万元

8.          “Immune response to allogeneic  hESC-derived endothelial cells in hu-mice” NIH 1RC1 HL100117 2010.04-2012.03 

9.          “Role of CD47 in xenograft rejection   by macrophages”  NIH R01 AI064569 ,2007.12-2011.11

10.      国家海外杰出青年B类   2004.01-2006.12      

11.     "Mechanisms by which IFN-γ  separates GVHD and GVL” NIH P01 CA111519-Project 2,2006.08-2011.07 

12.     “Characterization of immunoregulatory  agents in humanized mice” Genzyme Corporation Research Grant,2007.07-2010.06

13.     “Mixed chimerism as an approach for  induction of islet xenograft tolerance” Juvenile Diabetes Research Foundation; JDRF1-2005-722005.03-2008.02

14.      “Mechanisms by which IL-12 dissociates   GVL Effects from GVHD” American Cancer Society RSG LIB-104857,2003.07-2007.06

15.      Feasibility of xenograft tolerance induction   by mixed chimerism” Juvenile Diabetes Research Foundation, JDRF 1-2001-770  2001.08-2004.07 

16.     “Tolerance Induction Across Discordant  Xenogeneic Barriers by Bone Marrow 、Transplantation” Juvenile Diabetes Research Foundation, JDRF 1-1999-573,1999.10-2001.09

17.      Compatibility of swine stem cells and   human stroma” NIH/NHLBI, 5 R01 HL54038,1998.08-2003.07

 

发表文章:

1.     Obata F, Ito I, Ito K, Abe A, Ohkubo M, Onda K, Yang YG, Watanabe K, Kashiwagi N.  Sequence analysis and HLA genotyping of a novel  HLA-DR14 allele.  Immunogenetics  1990;32:313-320. 

2.     Obata F, Ito K, Ito I, Yang YG, Ohkubo M, Watanabe K, Kashiwagi N.  HLA-DR gene frequencies in the Japanese population obtained by oligonucleotide genotyping.  Tissue Antigens 1991;38:124-132.

3.    Yang YG, Ohta S, Yamada S, Shimizu M, Takagaki Y.  Diversity of T-cell receptor d-chain cDNA in the thymus of a one-month-old pig.  J. Immunol. 1995;155:1981-1993.

4.     Yang YG, Glaser RM, Monroy R, Swenson K, Sykes M.  Enhanced porcine hematopoiesis in mice receiving donor-specific interleukin-3.  Transplant Proc.  1996;28:655-655.

5.     Yang YG, Sergio JJ, Monroy R, Swenson K, Sykes M.  Donor-specific growth factors promote swine hematopoiesis in SCID mice.  Xenotransplantation 1996;3:92-101.

6.     Yang YG, Sergio JJ, Pearson DA, Szot GL, Shimizu A, Sykes M.  Interleukin-12 preserves the graft-vs-leukemia effects of allogeneic T cells while inhibiting graft-vs-host disease in mice.  Blood  1997;90:4651-4660.

7.     Yang YG, Dey B, Sergio JJ, Pearson DA, Sykes M.  IL-12 induces complete protection from hyperacute GVHD and GVHD-associated immunodeficiency in a full haplotype-mismatched murine bone marrow transplantation model.  Transplantation.  1997;64:1343-1352.

8.     Yang YG, Sergio JJ, Sykes M.  Engraftment of discordant xenogeneic swine bone marrow cells in immunodeficient mice.  Xenotransplantation  1997;4:235-244.

9.     Day B., Yang YG, Szot GL, Pearson DA, Sykes M.  IL-12 alters GVHD-associated donor T cell activation and expansion.  Blood  1998;91:3315-3322.

10.  Yang YG, DeGoma E, Ohdan H, Bracy JL, Xu Y, Iacomini J, Thall AD, Sykes M.  Tolerization of anti-Gala1-3Gal natural antibody-forming B cells by induction of mixed chimerism.  J. Exp. Med.  1998;187: 1335-1342. PMCID: PMC2212239

11.  Yang YG, DeGoma E, Sergio JJ, Sykes M.  B cell reconstitution and xenoreactive anti-pig natural antibody production in scid mice reconstituted with immunocompetent B cells from varying sources. Transplantation  1998;66:89-95.

12.  Sykes M., Ohdan H, Manilay JO, Wekerle T, Yang YG.  Hematopoietic chimerism and tolerance of T cells, B cells, and NK cells.  Transplant Proc.  1998;30:4020-4020.

13.  Yang YG, Dey BR, Pearson DA, Sykes M.  Donor-derived Interferon g is required for inhibition of acute GVHD by interleukin 12.  Journal of Clinical Investigation  1998;102:2126-2135. PMCID: PMC509167

14.  Ohdan H., Yang YG, Sykes M.  Reduction of anti-Gala1-3Gal natural antibodies in sera of a1,3Gal-galacytosyltransferase-deficient mice receiving Gal-positive bone marrow transplantation.  Transplant Proc.  1999;31:945-946.

15.  Dey BR, Yang YG, Preffer F, Shimizu A, Swensen K, Dombkowski D, Sykes M.  The fate of donor TCR transgenic T cells with known host antigen specificity in a GVHD model.  Transplantation  1999;68:141-149.

16.  Pelot MR, Pearson DA, Swenson K, Zhao G, Sachs J, Yang YG, Sykes M.  Lymphohematopoietic graft-versus-host reaction without graft-versus-host disease induced in murine mixed chimerism established with a Cyclophosphamide-based non-myeloablative conditioning regimen.  Biology of Blood and Marrow Transplantation  1999;5:133-143.

17.  Ohdan H., Yang YG, Shimizu A, Sykes, M.  Mixed chimerism induced without lethal conditioning prevents T cell- and anti-Gala1,3Gal-mediated graft rejection. Journal of Clinical Investigation 1999;104:281-290. PMCID: PMC408419

18.  Yang YG, Chen AM, Zhou Y, Sykes M.  Role of antibody-independent complement activation in rejection of porcine bone marrow cells.  Transplantation  2000;69:163-165.

19.  Cheng T, Rodrigues N, Shen H, Yang YG, Dombkowski D, Sykes M, Scadden DT.  Hematopoietic Stem Cell Quiescence Maintained by p21cip1/waf1.  Science 2000;287:1804–1808.

20.  Ohdan H.; Yang YG; Swenson KG; Thall AD; Sykes M.  In vivo T cell depletion enhances production of anti-GalaGal natural antibodies in a1,3-galactosyltransferase deficient mice.  Transplantation  2000;69:910-913.

21.  Yang YG*, Chen AM, Sergio JJ, Theodore P, Garrett LJ, Awwad M, Bodine DM, Sachs DH, Sykes M.  Development and analysis of transgenic mice expressing porcine hematopoietic cytokines: A model for achieving durable porcine hematopoietic chimerism across an extensive xenogeneic barrier.  Xenotransplantation  2000;7:58-64.

22.  Abe M, Chen AM, Qi J, Sachs DH, Sykes M, Yang YG*. Porcine stem cell factor (SCF) facilitates long-lasting porcine hematopoietic chimerism in murine recipients. Transplant Proc. 2000;32:1047-1047.

23.  Chen AM, Zhou Y, Swenson K, Sachs DH, Sykes M, Yang YG*.  Porcine stem cell engraftment and seeding of murine thymus with class II+ cells in mice expressing porcine cytokines: Toward tolerance induction across discordant xenogeneic barriers.  Transplantation  2000;69:2484-2490.

24.  Ohdan H, Swenson KG, Gray HSK, Yang YG, Xu Y, Thall AD, Sykes M.  Mac-1-negative B-1b phenotype of natural antibody-producing cells, including those responding to Gala1,3Gal epitopes in a1,3-galatosyltransferase deficient mice.  J. Immunol. 2000;165:5518-5529.

25.  Ohdan H, Yang YG, Swenson KG, Kitamura H, Sykes M.  T cell and B cell tolerance to GALa1,3GAL-expressing heart xenografts is achieved in a1,3-galactosyltransferase-deficient mice by nonmyeloablative induction of mixed chimerism.  Transplantation  2001;71:1532-1542.

26.  Ohdan H, Swenson KG, Kitamura H, Yang YG, Sykes M.  Tolerization of Gal alpha 1,3Gal-reactive B cells in pre-sensitized alpha 1,3-galactosyltransferase-deficient mice by nonmyeloablative induction of mixed chimerism. Xenotransplantation 2001;8:227-238

27.  Yang YG*, Qi, J, Wang MG, Sykes M.  Donor-derived interferon g separates graft-versus-leukemia effects and graft-versus-host disease-inducing activity of donor CD8 T cells.  Blood 2002;99:4207-4215.

28.  Abe M, Cheng J., Qi J., Glaser, RM, Thall, AD, Sykes M., Yang YG*.  Elimination of porcine hematopoietic cells by macrophages in mice. J Immunol 2002;168:621-628.

29.  Abe M., Qi J. Sykes M., and Yang YG*.  Mixed chimerism induces donor-specific T cell tolerance across a discordant xenogeneic barrier. Blood  2002;99:3823-3829. PMID: 11986242

30.  Preffer FI, Dombkowski D., Sykes M., Scadden D., Yang YG.  Lineage negative side population [SP] cells with restricted hematopoietic capacity circulate in normal human adult blood: Immunophenotypic and functional characterization.  Stem Cells 2002;20:417-427.

31.  LeGuern A, Giovino MA, Abe M, Qi J, Down J, Sachs DH, Sykes M, and Yang, YG*.  Stem cell activity of c-kit+ porcine hematopoietic cells. Exp. Hematol. 2003;31:833-840.

32.  Kawahara T, Ohdan H, Zhao G, Yang YG, Sykes M. Peritoneal cavity B cells are precursors of splenic IgM natural antibody-producing cells. J Immunol 2003;171:5406-5414.

33.  Lechner A, Yang YG, Blacken RA, Wang L, Nolan AL, Habener JF.  No evidence for significant transdifferentiation of bone marrow into pancreatic b-cells in vivo.  Diabetes 2004;53:616-623.

34.  Lan P, Wang L, Diouf B, Eguchi H, Su H, Bronson R, Sachs DH, Sykes M, Yang YG*. Induction of human T cell tolerance to porcine xenoantigens through mixed hematopoietic chimerism.  Blood 2004;103:3964-3969.

35.  Yang YG*, Wood JC, Lan P, Wilkinson RA, Sykes M, Fishman JA, Patience C.  Porcine endogenous retrovirus is not transmitted directly to human cells, but infection is mediated by mouse retrovirus in long-term human-porcine chimeric mice.  J Clin Invest 2004;114:695-700. PMCID: PMC514590

36.  Eguchi H, Knosalla C, Lan P, Cheng J, Diouf B, Wang L, Abe M, Schuurman H-J, Sachs DH, Sykes M, Cooper DKC, Yang YG*.  T cells from presensitized donors fail to cause graft-versus-host disease in a pig-to-mouse xenotransplantation model.  Transplantation 2004;78:1609-1617.

37.  Giovino MA, Wang H, Sykes M, Yang YG*.  Role of VLA-4 and VLA-5 in ex vivo maintenance of human and porcine hematopoiesis in human bone marrow stroma-supported long-term cultures.  Exp. Hematol. 2005;33:363-370.

38.  Xu Y, Yang YG, Ohdan H, Ryan D, Harper D, Wu C, Kruger-Grey HS, Thall AD, Awwad M, Sykes M. Characterization of anti-Gal antibody-producing cells of baboons and humans.  Transplantation 2006;81(6):940-948.

39.  Sun A, Wei H, Sun R, Xiao W, Yang YG, Tian Z. Human interleukin-15 improves engraftment of human T cells in NOD-SCID mice. Clin Vaccine Immunol. 2006;13(2):227–234.

40.  Lan P, Tonomura N, Wang S, Yang YG*.  Reconstitution of a functional human immune system in immunodeficient mice through combined human fetal thymus/liver and CD34+ cell transplantation.  Blood 2006;108:487–492.

41.  Asavaroengchai W, Wang S, Wang L, Bronson R, Sykes M, Yang YG*.  An essential role for IFN-g in regulation of alloreactive CD8 T cells following allogeneic hematopoietic cell transplantation.  Biology of Blood and Marrow Transplantation  2007;13:46-55. PMCID: PMC1893089

42.  Wang H, VerHalen J, Madariaga ML, Xiang S, Wang S, Lan P, Oldenborg P-A, Sykes M, Yang YG*.  Attenuation of phagocytosis of xenogeneic cells by manipulating CD47. Blood 2007;109:836-842. PMCID: PMC1785095

43.  Ide K, Wang H, Liu J, Wang X, Asahara T, Sykes M, Yang YG*, Ohdan H*. Role for CD47-SIRPa signaling in xenograft rejection by macrophages. Proc Natl Acad Sci USA 2007;104(12):5062-5066. PMCID: PMC1829264

44.  Li X, Jiang L, Wang Y, Xiao Y, Huang Y, Yao Q, Yang Y, Wu X.  Inhibition of angiogenesis by a novel small peptide consisting of the active fragments of platelet factor-4 and vasostatin.  Cancer Lett. 2007;256:29-32.

45.  Cho PS, Lo DP, Wikiel KJ, Rowland HC, Coburn RC , McMorrow IM, Goodrich JG, Arn JS, Billiter B, Houser S, Shimizu A, Yang YG, Sachs DH, Huang CA. Establishment of transplantable porcine tumor cell lines derived from MHC-inbred miniature swine. Blood 2007;110:3996-4004.

46. Wang H, Madariaga ML, Wang S, Van Rooijen N, Oldenborg PA, Yang YG*.  Lack of CD47 on nonhematopoietic cells induces split macrophage tolerance to CD47null cells.  Proc Natl Acad Sci USA 2007;104:13744-13749. PMCID: PMC1949343

47. Tonomura N, Habiro K, Shimizu A, Sykes M, Yang YG*.  Antigen specific human T cell responses and T cell-dependent production of human antibodies in a humanized mouse model. Blood 2008;111:4293-4296.

48. Tonomura N, Shimizu A, Wang S, Yamada K, Tchipashvili V, Weir GC, Yang YG*.  Pig islet xenograft rejection in a mouse model with an established human immune system.  Xenotransplantation 2008;15:129-135.

49.  Kumar P, Ban HS, Kim SS, Wu H, Pearson T, Greiner DL, Laouar A, Yao J, Haridas V, Habiro K, Yang YG, Jeong JH, Lee KY, Kim YH, Kim SW, Peipp M, Fey GH, Manjunath N, Shultz LD, Lee SK, Shankar P.  T Cell-Specific siRNA Delivery Suppresses HIV-1 Infection in Humanized Mice.  Cell 2008;134:577-586. PMCID: PMC2943428

50.  Shimizu I, Fudaba Y, Shimizu A, Yang YG, Sykes M. Comparison of human T cell repertoire generated in xenogeneic porcine and human thymus grafts.  Transplantation. 2008;86:601-610.

51.  Wu X, Yan Q, Huang Y, Huang H, Su Z, Xiao J, Zeng Y, Wang Y, Nie C, Yang YG, Li X. Isolation of a novel basic FGF-binding peptide with potent antiangiogenetic activity.  J Cell Mol Med. 2010;14:351-356 [2008 Epub ahead of print]

52.  Xing C, Lee S, Kim WJ, Jin G, Yang YG, Ji X, Wang X, Lo EH. Role of oxidative stress and caspase 3 in CD47-mediated neuronal cell death. J Neurochemistry 2009;108:430-436. PMCID: PMC3705576

53.  Wang H, Asavaroengchai W, Yeap BY, Wang MG, Wang S, Sykes M, Yang YG*. Paradoxical effects of IFN‑g in graft-vs.-host (GVH) disease reflect promotion of lymphohematopoietic GVH reactions and inhibition of epithelial tissue injury. Blood 2009;113:3612-3619. PMCID: PMC2668848

54.  Jin G, Tsuji K, Xing C, Yang YG, Wang X, Lo EH. CD47 gene knockout protects against transient focal cerebral ischemia in mice. Exp Neurol 2009;217:165-170 (Epub 2009 Feb 20). PMCID: PMC3722607

55.  Xing C, Lee S, Kim WJ, Wang H, Yang YG, Ji X, Wang X, Lo EH. Neurovascular effects of CD47 signaling: promotion of cell death, inflammation and suppression of angiogenesis in brain endothelial cells in vitro. J Neurosci Res 2009;87:2571-2577. PMCID: PMC3712846

56.  Habiro K, Sykes M, Yang YG*.  Induction of human T cell tolerance to pig xenoantigens via thymus transplantation in mice with an established human immune system.  American Journal of Transplantation 2009;9:1324-1429. PMCID: PMC2752337.

57.  Brainard DM, Seung E, Frahm N, Cariappa A, Bailey CC, Hart WK, Shin HS, Brooks SF, Knight HL, Eichbaum Q, Yang YG, Sykes M, Walker BD, Freeman GJ, Pillai S, Westmoreland SV, Brander C, Luster AD, Tager AM. Induction of robust cellular and humoral virus-specific adaptive immune responses in HIV-infected humanized BLT mice. J Virol. 2009;83:7305-7321. PMCID: PMC2704767

58.  Wang Y, Lin H, Lin S, Qu J, Xiao J, Huang Y, Xiao Y, Fu X, Yang YG, Li X. Cell-penetrating peptide TAT-mediated delivery of acidic FGF to retina and protection against ischemia-reperfusion injury in rats. J Cell Mol Med 2010;14(7):1998-2005 [2009 Epub ahead of print].

59.  Kim SS, Peer D, Kumar P, Subramanya S, Wu H, Asthana D, Habiro K, Yang YG, Manjunath N, Shimaoka M, Shankar P. RNAi-mediated CCR5 silencing by LFA-1-targeted nanoparticles prevents HIV infection in BLT mice.  Molecular Therapy 2010;18:370-6. PMCID: PMC2839291

60.  Xia J, Liu W, Hu B, Tian Z, Yang YG*.  IL-15 promotes regulatory T cell function and protects against diabetes development in NK-depleted NOD mice. Clin Immunol. 2010;134:130-9. Epub 2009 Oct 28.

61.  Wang Y, Wang H, Wang S, Fu Y, Yang YG*. Survival and function of CD47-deficient thymic grafts in mice.  Xenotransplantation 2010;17:160-165.

62.  Wang H, Wu X, Wang Y, Oldenborg PA, Yang YG*. CD47 is required for suppression of allograft rejection by donor specific transfusion.  J Immunol. 2010;184:3401-3407. PMCID: PMC3670954

63.  Onoe T, Kalscheuer H, Chittenden M, Zhao G, Yang YG, Sykes M. Homeostatic expansion and phenotypic conversion of human T cells depend on peripheral interactions with APCs. J Immunol. 2010;184:6756-65. PMCID: PMC3086709

64.  Wang C, Wang H, Ide K, Wang Y, Van Rooijen N, Ohdan H, Yang YG*. Human CD47 expression permits survival of porcine cells in immunodeficient mice that express SIRPa capable of binding to human CD47. Cell Transplant 2011;20:1915-1920. PMCID: PMC3670959

65.  Bai H, Chen K, Gao YX, Arzigian M, Xie YL, Malcosky C, Yang YG, Wu WS, Wang ZZ. Bcl-xL enhances single-cell survival and expansion of human embryonic stem cells without affecting self-renewal. Stem Cell Research 2011;8:26–37. Epub 2011 Aug 16.

66.  Onoe T, Kalscheuer H, Chittenden M, Zhao G, Yang YG, Sykes M. Human natural regulatory T cell development, suppressive function and post-thymic maturation in a humanized mouse model. J Immunol 2011;187(7):3895-903. PMCID: PMC3201793

67.  Yang Y, Wang H, Yu H, Yeap BY, Liang T, Wang G, Cheng T, Yang YG*. IFN-g promotes graft-versus-leukemia effects without directly interacting with leukemia cells in mice after allogeneic hematopoietic cell transplantation. Blood 2011;118(13):3721-4. Epub 2011 Aug 11. PMCID: PMC3186344.

68.  Hu Z, van Rooijen N, Yang YG*. Macrophages prevent human red blood cell reconstitution in immunodeficient mice. Blood 2011;118(22):5938-46. Epub 2011 Sep 16. PMCID: PMC3228505.

69.  Kalscheuer H, Danzl N, Onoe1 T, Faust T, Winchester R, Goland R, Greenberg E, Spitzer TR, Savage DG, Tahara H, Choi G, Yang YG, Sykes M. A model for personalized in vivo analysis of human immune responsiveness. Sci Transl Med. 2012;4(125):125ra30. PMCID: PMC3697150

70.  Hu Z, Yang YG*. Full reconstitution of human platelets in humanized mice after macrophage depletion. Blood 2012;120(8):1713-6. Epub 2012 Jul 6. PMCID: PMC3429310.

71.  Wang H, Yang Y, Wang G, Wang S, Yeap BY, Sykes M, Yang YG*. 2012. Donor Bone Marrow-Derived T Cells Inhibit GVHD Induced by Donor Lymphocyte Infusion in Established Mixed Allogeneic Hematopoietic Chimeras. PLoS ONE 7:e47120. PMCID: PMC3471915

72.  Wang Y, Wang H, Bronson R, Fu Y, Yang YG*. Rapid dendritic cell activation and resistance to allotolerance induction in anti-CD154-treated mice receiving CD47-deficient donor-specific transfusion. Cell Transplant 2014;23(3):355-63. 2013 Jan 2. [Epub ahead of print] PMID: 23295133; PMCID: PMC3732805

73.  Wu X, Huang H, Wang C, Lin S, Huang Y, Wang Y, Liang G, Yan Q, Xiao J, Wu J1, Yang YG, Li X*. Identification of a novel peptide that blocks basic fibroblast growth factor-mediated cell proliferation, Oncotarget. 2013;10:1819-28.

74.  Wang Y, Wang H, Xia J, Liang T, Wang G, Li X, Yang YG*. Activated CD8 T cells acquire NK1.1 expression and preferentially locate in the liver in mice after allogeneic hematopoietic cell transplantation. Immunology Letters 2013 Feb;150(1-2):75-8. PMID: 23291124; PMCID: PMC3602380

75.  Navarro-Alvarez N, Yang YG*. Lack of CD47 on donor hepatocytes promotes innate immune cell activation and graft loss: a potential barrier to hepatocyte xenotransplantation. Cell Transplant 2014;23(3):345-54. 2013 Feb 7. [Epub ahead of print] PMID: 23394628; PMCID: PMC3751988

76.  Huang SXL, Islam MN, O’Neil J, Hu Z, Yang YG, Chen YW, Mumau M, Green MD, Vunjak-Novakovic G, Battachariya J, Snoeck HW. Efficient generation of lung and airway epithelial cells from human pluripotent stem cells. Nat Biotechnol. 2014;32(1):84-91. doi: 10.1038/nbt.2754. Epub 2013 Dec 1.

77.  Rong Z, Wang M, Hu Z, Stradner M, Zhu S, Kong H, Yi H, Goldrath A, Yang YG, Xu Y, Fu X. An effective approach to prevent immune rejection of human ESC-derived allografts. Cell Stem Cell 2014;2:14(1):121-30. doi: 10.1016/j.stem.2013.11.014. PMCID: PMC4023958.

78.  Wang Y, Wang H, Ren L, Weng Q, Bao Y, Tian H, Yang YG*, Li X. Non-mitogenic form of acidic fibroblast growth factor protects against graft-versus-host disease without accelerating leukemia. Int Immunopharmacol. 2014 Dec;23(2):395-9.

79.  Pan Y, Wang F, Liu Y, Jiang J, Yang YG*, Wang H*. Studying the mechanism of CD47-SIRPα interactions on red blood cells by single molecule force spectroscopy. Nanoscale. 2014;7:6(17):9951-4. doi: 10.1039/c4nr02889a.

80.  Sui M, Wu U, Hu X, Zhang H, Jiang J, Yang YG*, Niu J*. Low prevalence of hepatitis B virus infection in patients with autoimmune diseases in a Chinese patient population. J Viral Hepatitis 2014;21: 925–929.

81.  Hu L, Cheng H, Gao Y, Shi M, Liu Y, Hu Z, Xu J, Qiu L, Yuan W, Leung AY, Yang YG, Cheng T. The antioxidant N-acetyl-L-cysteine increases engraftment of human hematopoietic stem cells in immune-deficient mice. Blood. 2014 Nov 13;124(20):e45-8. PMCID: PMC4231425

82.  Pan YG, Wang F, Liu YH, Yang YG*, Wang HD*. Single-molecule-force spectroscopy study of the mechanism of interactions between TSP-1 and CD47. Science China Chemistry 2014;57: 1716-1722.

83.  Sykes M, Zhao Y, Yang YG.  Tolerance induction in xenotransplantation.  World Journal of Surgery  1997;21:932.

84.  Yang YG, Sykes M.  The role of interleukin-12 in preserving the graft-versus-leukemia effect of allogeneic CD8 T cells independently of GVHD.  Leukemia and lymphoma 1999;33:409-420.

85.  Yang YG.  The role of interleukin-12 and interferon-g in GVHD and GVL. Cytokines, Cellular and Molecular Therapy 2000;6:41-46.

86.  Yang YG, Sykes M.  Graft-versus-Host Disease and Graft-versus-Leukemic Effect in Allogeneic Bone Marrow Transplantation: Role of Interferon-g.  Graft 2002;5:250-255.

87.  Yang YG.  Application of xenogeneic stem cells for induction of transplantation tolerance: Present state and further directions.  Springer Seminars in Immunopathology 2004;26:187-200.

88.  Yang YG, Wang H, Asavaroengchai W, Dey BR. Role of Interferon-gamma in GVHD and GVL.  Cell Mol Immunol. 2005;2:323-329.

89.  Yang YG, Sykes M. Tolerance in xenotransplantation.  Curr Opin Organ Transplant 2007;12:169–175.

90.  Yang YG, Sykes M. Xenotransplantation - Current Status and a Perspective on the Future. Nature Reviews Immunology 2007;7:519-531.

91.  Soto-Gutierrez A, Yagi H, Uygun BE, Navarro-Alvarez N, Uygun K, Kobayashi N, Yang YG, Yarmush ML.  Cell Delivery: From Cell Transplantation to Organ Engineering. Cell Transplant 2010;19: 655–665.. [Epub ahead of print] PMCID: PMC2957541

92.  Yang YG. CD47 in xenograft rejection and tolerance induction.  Xenotransplantation 2010;17:267–273. PMCID: PMC3670961

93.  Navarro-Alvarez N and Yang YG. CD47 a new player in phagocytosis and xenograft rejection.  Cell Mol Immunol  2011;8:285-288 [Epub ahead of print, January 24, 2011]. PMCID: PMC3644051.

94.  Hu Z, Yang YG. Human lymphohematopoietic reconstitution and immune function in immunodeficient mice receiving cotransplantation of human thymic tissue and CD34+ cells. Cell Mol Immunol. 2012;9:232-236. Feb 6 2012. doi: 10.1038/cmi.2011.63. [Epub ahead of print].

95.  Wang H, Yang YG. Innate cellular immunity and xenotransplantation.  Curr Opin Organ Transplant. 2012;17:162-7 (2012 Jan 18. [Epub ahead of print]). PMCID: PMC3324331

96.  Wang H, Yang YG. The complex and central role of interferon-g in graft-versus-host disease and graft-versus-tumor activity. Immunol Rev. 2014 Mar;258(1):30-44. NIHMSID # 579492

 

参编书籍:

1.     Sykes M, Dey B, Yang Y.G. IL-12 effects on GVHD and GVL. In: Graft-Vs.-Host Disease; Ferrara J.L.M. Deeg, H.J., Burakoff, S.J. (Eds.), New York, Marcel Decker Inc., 1997, pp. 784.

2.     Li HW, Yang YG, Sykes M. Thymic Education of Human T Cells and Regulatory T Cell Development in Humanized Mice (Chapter 11). In: Humanized Mice for HIV Research; Springer Science New York; 2014, pp.127.

3.     Hu Z, Yang YG. Biology of Human Hematopoietic Stem Cell Xenotransplantation in Mice (Chapter 5). In: Humanized Mice for HIV Research; Springer Science New York; 2014, pp.53.

 


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